Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease
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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease
Bittar, E.E.
Elsevier Science & Technology
07/2005
264
Dura
Inglês
9780444515001
15 a 20 dias
Caveolae are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects.
Section 1: Caveolae organization and role in lipid cholesterol metabolism. Lipid rafts and caveolae organization. Caveolae and the regulation of cellular cholesterol homeostasis. Section 2: Caveolae and the regulation of endocytosis. The Caveolae Internalization Machinery. Lipid raft mediated entry of bacteria into host cells. Section 3: Examples of the role of caveolins in cell signaling. The caveolin interaction with the endothelial nitric oxide synthase (eNOS). Caveolae and Estrogen Receptor Signaling. eNOS regulation by sphingosine 1-phosphate and caveolin. Insulin signaling and caveolae. Section 4: Caveolae and pathologies. Caveolin-3, Caveolae, and Hereditary Muscle Diseases. Caveolae and Caveolins in the Vascular System. Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.
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Caveolae are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects.
Section 1: Caveolae organization and role in lipid cholesterol metabolism. Lipid rafts and caveolae organization. Caveolae and the regulation of cellular cholesterol homeostasis. Section 2: Caveolae and the regulation of endocytosis. The Caveolae Internalization Machinery. Lipid raft mediated entry of bacteria into host cells. Section 3: Examples of the role of caveolins in cell signaling. The caveolin interaction with the endothelial nitric oxide synthase (eNOS). Caveolae and Estrogen Receptor Signaling. eNOS regulation by sphingosine 1-phosphate and caveolin. Insulin signaling and caveolae. Section 4: Caveolae and pathologies. Caveolin-3, Caveolae, and Hereditary Muscle Diseases. Caveolae and Caveolins in the Vascular System. Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
