Chemical Tools in Microbiology 1

1. Integration of bioinformatic and chemoproteomic tools for the study of enzyme conservation in closely related bacterial species 2. A Ligand Selection Strategy to Customize Small Molecule Probes for Activity-Based Protein Profiling (LS-ABPP) 3. Activity-based probes for bacterial histidine kinases 4. BSH-TRAP: Bile salt hydrolase tagging and retrieval with activity-based probes 5. Detecting and Identifying Glycoside Hydrolases Using Cyclophellitol-Derived Activity-Based Probes 6. Chemical proteomics for identifying short-chain fatty acid modified proteins in Salmonella 7. Kinetic dissection of macromolecular complex formation with minimally-perturbing fluorescent probes 8. Mobilization of Cryptic Antibiotic Biosynthesis Loci from Human-Pathogenic Nocardia 9. Endogenous Enzymes Enable Antimicrobial Activity 10. Identification of terpene synthases in higher fungi: combining analytical and bioinformatic methods 11. Bile salt hydrolase profiling by fluorogenic probes in the human gut microbiome 12. Optimized APEX2 peroxidase-mediated proximity labeling in fast- and slow-growing mycobacteria

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• Microbiologia (não médica)
• Biologia molecular
• Bioquímica

chemical probes; fluorescent probes; enzyme function; metabolites; peptidoglycans