Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

1. Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Down syndrome Eugene Yu 2. The trisomy paradox: gene expression dysregulation domains Stylianos Antonarakis 3. Influence of allelic differences in mouse models of Down syndrome Randall J. Roper 4. Modelling Down syndrome in cells: from stem cells to organoids Dean Nizetic 5. Modelling Down syndrome in animals from the early stage to the new generation of models Yann Herault 6. Mapping behavioral landscapes in Down syndrome animal models Maria Martinez de Lagran 7. Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of Chromosome 21 Frances Kendra Wiseman 8. Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome Carmen Martinez Cue 9. Focusing on cellular biomarkers: the endolysosomal pathway in Down syndrome Marie Claude Potier 10. Forecasting the future roadmap for Down syndrome preclinical research William Mobley

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• Neurociências
• Fisiológico e neuro-psicologia, biopsicologia