Separation Methods in Drug Synthesis and Purification

Preface Klara Valko

1. Comparison of various modes and phase systems for analytical HPLC

Pavel Jandera

2. Fast-generic HPLC methods

Ian M. Mutton

3. Advances in capillary electrochromatography

Jose Luis Dores-Sousa, Jelle De Vos, Debby Mangelings and Sebastiaan Eeltink

4. Coupled chromatographyemass spectrometry techniques for the analysis of combinatorial libraries

Steve Lane

5. Experimental design-based optimization strategies for chromatographic and capillary electrophoretic separations

J. Viaene and Y. Vander Heyden

6. Computer-aided HPLC method development for quality control of complex drug mixtures--An application example for DryLab

Halina Katsialevich, Hans-Juergen Rieger, Imre Molnar and Arnold Zoeldhegyi

7. The flexible application of automated preparative purification platforms within drug discovery

Jennifer Kingston, Neil Sumner, Katie Proctor and Elisabetta Chiarparin

8. Strategies for the development of process chromatography as a unit operation for the pharmaceutical industry

Drew Katti

9. Recent developments in liquid and supercritical fluid chromatographic enantioseparations

Debby Mangelings, Sebastiaan Eeltink and Yvan Vander Heyden

10. Basis and pharmaceutical applications of thin-layer chromatography

Huba Kalasz, Maria Bathori and Klara Valko

11. Recent advances in quantitative structureeretention relationships

Roman Kaliszan

12. Capillary electrophoresis for drug analysis and physicochemical characterization

Susana Amezqueta, Xavier Subirats, Elisabet Fuguet, Clara Rafols and Marti Roses

13. Application of HPLC measurements for the determination of physicochemical and biomimetic properties to model in vivo drug distribution in support of early drug discovery

Klara L. Valko

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• Química analítica
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analytical HPLC; fast generic HPLC; capillary electrochromatography; CEC; coupled chromatography; mass spectrometry; combinatorial libraries; optimization strategies; CZE; computer-aided HPLC; Quality Control; process chromatography; automated preparative HPLC; liquid chromatographic enantioseparation; thin-layer chromatography; quantitative structure- retention relationships; QSRR; capillary electrophoresis; physicochemical properties; surrogate biological processes; biomimetic HPLC