Spinal Drug Delivery

Spinal Drug Delivery

Yaksh, T.L.

Elsevier Health Sciences

05/1999

634

Dura

Inglês

9780444829016

0444829016

15 a 20 dias

1815

Provides a comprehensive compendium of issues related to the spinal delivery of drugs. This text begins with a review of the early history, reflecting the development of the spinal cord as a route of spinal drug delivery. It is of interest to scientists, toxicologists, chemists, and clinicians.
The history of spinal drug delivery - the evolution of lumbar puncture and spinal narcosis, D.C. Mackey; comparative spinal anatomy of vertebrates, R. Nieuwenhuys; spinal anatomy of experimental animals, T.F. Fletcher and S.A. Malkmus; gross anatomy of the human vertebral column, Q. Hogan; anatomy of DRG, intrathecal nerve roots, and epidural nerves with emphasis on mechanisms of neurotoxic injury, R.R. Myers and K. Olmarker; the spinal meninges and their role in spinal drug movement, C.M. Bernards; anatomy and physiology of the spinal vasculature, M. Marsala; spinal cerebrospinal fluid chemistry and physiology, A.A. Artru; epidural and intrathecal drug movement, C.M. Bernards; structure of extracellular space and physiochemical properties of molecules governing drug movement in brain and spinal cord, C. Nicholson; spinal pharmacokinetics, S.L. Shafer and A. Shafer; reaction of intrathecal and epidural spaces to infection and inflammation, R.O. Weller; animal models of intrathecal and epidural drug delivery, T.L. Yaksh and S.A. Malkmus; human spinal drug delivery - methods and technology, M.S. Wallace; general considerations in the formulation of drugs for spinal delivery, R.J.E. Grouts et al; material properties and bioreactivity, D.E. Albert and M.A. Hintz; general considerations in the characterization of drug action after spinal delivery, T.L. Yaksh; preclinical safety evaluation for spinal drugs, T.L. Yaksh et al; clinical implementation of agents for spinal delivery, J.C. Eisenach; spinally delivered analgesic drugs, S.E. Abram; local anesthetics acting on the spinal cord, A. Gokin and G. Strichartz; intrathecal chemotherapy, L. Bomgaars et al; intrathecally delivered medications for spasticity and dystonia, J.M. Meythaler; spinal drug delivery - contrast media, W.M. Haughton; spinal delivery of neurotrophins and related molecules, C.P. LeBel; spinal drug delivery - cellular implants, J. Sagen.
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