Stimuli-Responsive Hydrogels for Ophthalmic Drug Delivery

Part I: Properties and Preparation 1. Introduction to polymeric in-situ forming hydrogels 2. Biopolymers for in-situ forming hydrogels: synthesis, characterization, and toxicity 3. Chemistry and applications of biopolymer stimuli-responsive in-situ gels 4. Design, engineering, and fabrication of biopolymer in-situ forming hydrogels 5. Process optimization for design and fabrication of biopolymer stimuli-responsive hydrogels 6. Properties of biopolymeric in-situ hydrogels 7. Swelling and drug release kinetics of biopolymer in-situ forming hydrogels 8. Structural and load-bearing characteristics of biopolymer in-situ forming hydrogels 9. Functionalization of in-situ forming biopolymer hydrogels Part II: Applications in Ophthalmic Drug Delivery 10. Eye anatomy, physiology, and ocular barriers 11. In vitro and in vivo models in ophthalmic drug delivery 12. Formulation and ocular drug delivery routes 13. Clinical indications of stimuli-responsive hydrogels in ophthalmic drug delivery 14. Natural and synthetic materials for stimuli-responsive hydrogels in ophthalmic drug delivery 15. Characteristics and kinetics of in-situ forming hydrogels in ophthalmic drug delivery 16. Cell-laden stimuli-responsive hydrogels in ophthalmic drug delivery 17. Animal models and preclinical tests for evaluation of stimuli-responsive hydrogels in ophthalmic drug delivery 18. Biopolymer-based in-situ forming hydrogels: from laboratory to practical application 19. Commercially available stimuli-responsive hydrogels for ophthalmic drug delivery 20. Advantages and challenges of biopolymer in-situ hydrogels for ophthalmic drug delivery 21. Patents for biopolymer in-situ hydrogels for ophthalmic drug delivery

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• Biotecnologia
• Engenharia biomédica
• Ciência dos materiais

<P>Polymer; Hydrogels; <I>In-situ</I> hydrogels; Stimuli-responsive; Biopolymer; Process optimization; Drug release kinetics; Fabrication; Functionalization; Ophthalmic drug delivery; Ocular.</P>