Translational Approaches to Unravelling Non-Motor Symptoms of Parkinson's disease

A general clinical overview of the non-motor symptoms 1. General Clinical Overview 2. Stress/fatigue/ cognitive decline Sleep / autonomic failure A general clinical overview of the non-motor symptoms - psychiatric symptoms 3. Psychosis 4. Cognitive Decline Non-clinical Aspect of non-motor symptoms: Animal Models 5. Assessment and treatment of cognitive decline in rodent and primate models 6. Pain in PD models 7. Affective disorders in PD models 8. Sleep and circadian dysregulation and EEG disruption in rodent models of PD 9. Gut dysmotility in rodents and its central origin 10. Bladder dysfunction in rodent models of PD with a translational approach to bladder hyperreflexia in man 11. Long term adaptive changes to autonomically innervated smooth muscle contractility in a primate model of PD

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• Neurologia e neurofisiologia clínica

non-motor symptoms; cognitive decline; autonomic failure; dysfunction; dysregulation