Genome Stability

1. Genome stability: An evolutionary perspective

Part I Genome instability of viruses 2. Genetic instability of RNA viruses 3. Genome instability in DNA viruses

Part II Genome instability in bacteria and archaea 4. Genome instability in bacteria and archaea: Strategies for maintaining genome stability 5. Genome instability in bacteria: Causes and consequences 6. CRISPR - Bacterial immune system

Part III Genome stability of unicellular eukaryotes 7. From micronucleus to macronucleus: Programmed DNA rearrangement in ciliates is regulated by non-coding RNA molecules 8. Homologous recombination and nonhomologous end-joining repair in yeast

Part IV Genome stability in multicellular eukaryotes 9. Meiotic and mitotic recombination: First in flies 10. Genome stability in Drosophila: Mismatch repair and genome stability 11. Genome stability in Caenorhabditis elegans 12. Plant genome stability-General mechanisms 13. Genetic engineering in plants using CRISPRs

Part V Genome stability in mammals 14. Cell cycle control and DNA-damage signaling in mammals 15. The role of p53/p21/p16 in DNA damage signaling and DNA repair 16. Roles of RAD18 in DNA replication and post-replication repair (PRR) 17. Base excision repair and nucleotide excision repair 18. DNA mismatch repair in mammals 19. Repair of double-strand breaks by nonhomologous end joining; Its components and their function 20. Homologous recombination in mammalian cells: From molecular mechanisms to pathology 21. Telomere maintenance and genome stability 22. Chromatin, nuclear organization and genome stability in mammals 23. Role of DNA mthylation in genome stability 24. Non-coding RNAs in genome integrity

Part VI Human diseases associated with genome instability 25. Human diseases associated with genome instability 26. Cancer and genomic instability 27. Epigenetic regulation of the cell cycle & DNA-repair in cancer 28. Genomic instability and aging: Causes and consequences 29. The DNA damage response and neurodegeneration: Highlighting the role of the nucleolus in genome (in)stability

Part VII Effect of environment on genome stability 30. Diet and nutrition 31. Chemical carcinogens and their effect on genome and epigenome stability 32. Modern sources of environmental ionizing radiation exposure and associated health consequences

Part VIII Bystander and transgenerational effects: Epigenetic perspective 33. Sins of fathers through a scientific lens: Transgenerational effects 34. Radiation and chemical induced genomic instability as a driver for environmental evolution 35. Transgenerational genome instability in plants 36. Methods for the detection of DNA damage 37. Conserved and divergent features of DNA repair. Future perspectives in genome stability research 38. Off-target effects in genome editing

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• DNA e Genoma
• Genética (não médica)

Aberrations; Abiotic and biotic stresses; Acute vs chronic damage; Aerospace travel; Aging; Alternative end joining; Aplastic anemia; APOBEC3; Apoptosis; Arbovirus; Archaea; Bacteria; Base excision repair; BER; Bookmarker; Brain; Bystander effects; C. elegans; Cancer; Cell cycle; Cell cycle checkpoint; Checkpoint; Chemical carcinogens; Chemical ecology; Chromatin; Chromatin remodelers; Chromosomal instability; Chromosomal recombination; Chromosome stability; Chromosomes; Citrullination; Cockayne syndrome; Colorectal cancer; Common fragile sites; Conserved features; Coronavirus; Crossover; CSR; Dietary mutagens; Divergent features; Diversity-generating retro-element; DNA damage; DNA damage repair; DNA damage response; DNA damage tolerance; DNA double-strand break repair; DNA double-strand breaks; DNA methylation; DNA repair; DNA virus; DNA-damage checkpoint; DNA-damage response; Double Holliday junction; Double-strand break; Double-strand break (DSB); Double-strand break repair; Double-strand break-induced small RNAs (diRNAs); Drosophila; DSB repair; Dyskeratosis congenita; End joining; End resection; Environmental radiation; Epigenetic regulation; Epigenetics; Epigenome stability; Exosomes; Fanconi anemia; Future directions; Gene amplification; Gene transcription; Genetic and epigenetic mechanisms; Genetic diversity; Genetic instability; Genetic variability; Genome evolution; Genome instability; Genome integrity; Genome maintenance; Genome stability; Genomic instability; Genotoxins; H2AX; HDAC; HDR; Hereditary cancer; Heterochromatin; Homologous recombination; Homologous recombination (HR); Homology-directed repair; Horizontal gene transfer; Human disease; Idiopathic pulmonary fibrosis; Immunofluorescence microscopy; Influenza virus; Intergenerational response; Ionizing radiation; Ionizing Radiation; Lynch syndrome; Measles virus; Medical radiation; Meiosis; Meiotic recombination; Microsatellite instability; Mismatch repair; Mitochondrial DNA; Mitosis; MMR; Mobile genetic elements; Mutagenesis; Mutation; Mutation rate; Mutator; ncRNA; NER; Neurodegeneration; Neuron; NHEJ; Noncoding RNA; Non-coding RNA; Non-homologous end joining (NHEJ); Nonhomologous end-joining; Nonhomologous recombination; Nontargeted effects of radiation (NTE); Nuclear disaster; Nuclear organization; Nucleolar stress; Nucleolus; Nucleotide excision repair; Nutrients; Oxidative stress; p16; p21; p53; Photons; Photoreactivation; Piwi-interacting RNA (piRNA); Plant genome stability; Plants; Polymerase fidelity; Polyphenols; QDE-2 interacting small RNAs (qiRNAs); QDE-2-interacting small RNAs (qiRNAs); Rad18; Radon; rDNA; Recombination; Repeats; Replication stress; Restriction-modification systems; Reverse transcriptase; Ribosomal biogenesis; Ribosomal DNA; RNA dependent RNA polymerase; RNA virus; SCID; Senescence; Shelterin; Small interfering RNAs (siRNAs); Somatic cell mutation; SOS response; Sporadic cancer; Stress responses; Stress-induced mutagenesis; Stress-induced mutation; Synthesis-dependent strand annealing; Targeted gene replacement; Telomerase; Telomere; Telomeres; Template switch; The environment; Transcription; Transgenerational effects; Transgenerational response; Translation; Trans-lesion synthesis; Translocation; Translocations; Trichothiodystrophy; Unanswered questions; UV lesions; UV-sensitive syndrome; V(D)J recombination; Viral quasispecies; Virulence; Xeroderma pigmentosum; Yeast; ?H2AX foci