Redox Chemistry and Biology of Thiols
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portes grátis
Redox Chemistry and Biology of Thiols
Comini, Marcelo; Salinas, Gustavo; Alvarez, Beatriz; Trujillo, Madia
Elsevier Science & Technology
05/2022
746
Mole
Inglês
9780323902199
15 a 20 dias
450
Descrição não disponível.
1. Basic concepts of thiol chemistry and biology 2. Chemical basis of cysteine reactivity: Acidity and nucleophilicity 3. Computational functional analysis of cysteine residues in proteins 4. Global approaches for protein thiol redox state detection and quantification 5. Thiol oxidation by biologically-relevant reactive species 6. Thiyl radicals: formation, properties and detection 7. Detection of the oxidation products of thiols: disulfides, sulfenic, sulfinic and sulfonic acids 8. Biochemistry and detection of S-nitrosothiols 9. Thiol modification and signaling by biological electrophiles 10. Thioredoxin and glutathione reductases 11. Functional plasticity in the thioredoxin family: FeS-thio- and glutaredoxins 12. Glutathione and glutathione-dependent enzymes 13. Thiol and selenol-based peroxidases: Structure and catalytic properties 14. Thiol peroxidase-based redox relays 15. Compartmentalized disulphide bond formation pathways 16. Disulfide bond formation in Escherichia coli 17. Thiol-based redox probes 18. Selenocysteine-containing proteins 19. Overview of cysteine metabolism 20. Hydrogen sulfide and persulfides 21. The role of thiols in iron-sulfur cluster biogenesis 22. Thiol-based redox control in chloroplasts 23. Sugar-based cysteine thiols recruited for oxidative stress defence and redox regulation 24. Polyamine-based thiols in pathogens 25. Thiols in blood 26. A thiol chemistry perspective on redox medicine 27. Therapeutic applications of low-molecular-weight thiols and selenocompounds 28. Thiol targets in drug development to combat bacterial infections
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Acid-base; Acidity; Albumin; Allicin; ALR; Amino acid; Anemia; Bacillithiol; Bacterial thiol drug targets; Beta-lactamase; Bioinformatics; Blood; Catalysis; Catalytic mechanism; Chemoproteomics; Chloroplast; Coenzymea; Compartmentalization; Compartments; Covalent modification; Cysteine; Cysteine desulfurase; Denitrosation; Detoxification; Diffusion; Disulfide; Disulfide bond; Disulfide bond formation; Disulfide bond reduction; Disulfide isomerization; Dsb; DsbA; DsbAB; DsbB; DsbC; DsbD; DTT; EGFR; Eicosanoids; Electron transfer; Endogenous; Enzyme catalysis; ER; ERO1; Escherichia coli; Fatty acid hydroperoxide; Glutaredoxin; Glutathione; Glutathione peroxidase; Glutathione reductase; Glutathione transferase; Glutathionylspermidine; Glyoxalase 1 and 2; Gram-negative bacteria; Gyrase; H2O2; Hemoglobin; Hydrogen bond; Hydrogen peroxide; Hydrogen sulfide; Hydrogen sulfide detection; Hydrogen transfer; Hydroperoxides; Hydropersulfide; HyPer; Hyperglycinemia; IMS; Iodoacetamide; Iron regulation; Iron-sulfur cluster; Iron-sulfur cluster; Isoenzymes; KRAS; Leishmania; Lipoperoxidation; LMW thiols; Low molecular weight thiols; Machine learning; MAPEG; Metabolism; Methionine sulfoxide; MIA40; Michael addition; Mitochondria; Mycothiol; NADPH; NEM; Nitric oxide; Nitrosation; Nitrosothiols; Nitrosylation; NRF2; Nucleophilicity; Organelle; Organic hydroperoxide resistance protein; Organism; Oxidation; Oxidative stress; Oxidized lipids; Oxidoreductase; Oxidoreductases; PDI; Periplasm; Peroxidase; Peroxidatic cysteine; Peroxiredoxin; Peroxiredoxins; Persulfide; Persulfide detection; pKa; Plants; Plasma; Posttranslational modification; Protein biotechnology; Protein oxidation; Protein structure; Reactive nitrogen species; Reactive oxygen species; Reactivity; Recoding; Red blood cells; Redox; Redox balance; Redox bioinformatics; Redox biology; Redox drug targets; Redox drugs; Redox methods; Redox modeling; Redox proteomics; Redox sensor; Redox signaling; Redox-regulated proteins; Reduction; Reductive enzymes; Redundancy; Reversible addition; roGFP; roGFP2-based biosensors; ROS-producing antimicrobials; S-Bacillithiolation; SECIS; Selectivity; Selenium; Selenocysteine; Selenol; Selenoprotein; Signaling; S-Mycothiolation; Solvation; Specificity; Splicing; Steroids; Structural biology; Sugar-based LMW thiols; Sulfenic acid; Sulfinic acid; Sulfonic acid; Sulfur; Sulfur metabolism; TCEP; Thiol; Thiol oxidation; Thiol peroxidases; Thiolate; Thiol-based redox signaling; Thiols; Thioredoxin; Thioredoxin reductase; Thioredoxin/thioredoxin reductase; Thiyl radical; Transnitrosation; Transsulfuration; Trypanosoma; Trypanothione; Tryparedoxin; Tyrosine; UGA
1. Basic concepts of thiol chemistry and biology 2. Chemical basis of cysteine reactivity: Acidity and nucleophilicity 3. Computational functional analysis of cysteine residues in proteins 4. Global approaches for protein thiol redox state detection and quantification 5. Thiol oxidation by biologically-relevant reactive species 6. Thiyl radicals: formation, properties and detection 7. Detection of the oxidation products of thiols: disulfides, sulfenic, sulfinic and sulfonic acids 8. Biochemistry and detection of S-nitrosothiols 9. Thiol modification and signaling by biological electrophiles 10. Thioredoxin and glutathione reductases 11. Functional plasticity in the thioredoxin family: FeS-thio- and glutaredoxins 12. Glutathione and glutathione-dependent enzymes 13. Thiol and selenol-based peroxidases: Structure and catalytic properties 14. Thiol peroxidase-based redox relays 15. Compartmentalized disulphide bond formation pathways 16. Disulfide bond formation in Escherichia coli 17. Thiol-based redox probes 18. Selenocysteine-containing proteins 19. Overview of cysteine metabolism 20. Hydrogen sulfide and persulfides 21. The role of thiols in iron-sulfur cluster biogenesis 22. Thiol-based redox control in chloroplasts 23. Sugar-based cysteine thiols recruited for oxidative stress defence and redox regulation 24. Polyamine-based thiols in pathogens 25. Thiols in blood 26. A thiol chemistry perspective on redox medicine 27. Therapeutic applications of low-molecular-weight thiols and selenocompounds 28. Thiol targets in drug development to combat bacterial infections
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
Acid-base; Acidity; Albumin; Allicin; ALR; Amino acid; Anemia; Bacillithiol; Bacterial thiol drug targets; Beta-lactamase; Bioinformatics; Blood; Catalysis; Catalytic mechanism; Chemoproteomics; Chloroplast; Coenzymea; Compartmentalization; Compartments; Covalent modification; Cysteine; Cysteine desulfurase; Denitrosation; Detoxification; Diffusion; Disulfide; Disulfide bond; Disulfide bond formation; Disulfide bond reduction; Disulfide isomerization; Dsb; DsbA; DsbAB; DsbB; DsbC; DsbD; DTT; EGFR; Eicosanoids; Electron transfer; Endogenous; Enzyme catalysis; ER; ERO1; Escherichia coli; Fatty acid hydroperoxide; Glutaredoxin; Glutathione; Glutathione peroxidase; Glutathione reductase; Glutathione transferase; Glutathionylspermidine; Glyoxalase 1 and 2; Gram-negative bacteria; Gyrase; H2O2; Hemoglobin; Hydrogen bond; Hydrogen peroxide; Hydrogen sulfide; Hydrogen sulfide detection; Hydrogen transfer; Hydroperoxides; Hydropersulfide; HyPer; Hyperglycinemia; IMS; Iodoacetamide; Iron regulation; Iron-sulfur cluster; Iron-sulfur cluster; Isoenzymes; KRAS; Leishmania; Lipoperoxidation; LMW thiols; Low molecular weight thiols; Machine learning; MAPEG; Metabolism; Methionine sulfoxide; MIA40; Michael addition; Mitochondria; Mycothiol; NADPH; NEM; Nitric oxide; Nitrosation; Nitrosothiols; Nitrosylation; NRF2; Nucleophilicity; Organelle; Organic hydroperoxide resistance protein; Organism; Oxidation; Oxidative stress; Oxidized lipids; Oxidoreductase; Oxidoreductases; PDI; Periplasm; Peroxidase; Peroxidatic cysteine; Peroxiredoxin; Peroxiredoxins; Persulfide; Persulfide detection; pKa; Plants; Plasma; Posttranslational modification; Protein biotechnology; Protein oxidation; Protein structure; Reactive nitrogen species; Reactive oxygen species; Reactivity; Recoding; Red blood cells; Redox; Redox balance; Redox bioinformatics; Redox biology; Redox drug targets; Redox drugs; Redox methods; Redox modeling; Redox proteomics; Redox sensor; Redox signaling; Redox-regulated proteins; Reduction; Reductive enzymes; Redundancy; Reversible addition; roGFP; roGFP2-based biosensors; ROS-producing antimicrobials; S-Bacillithiolation; SECIS; Selectivity; Selenium; Selenocysteine; Selenol; Selenoprotein; Signaling; S-Mycothiolation; Solvation; Specificity; Splicing; Steroids; Structural biology; Sugar-based LMW thiols; Sulfenic acid; Sulfinic acid; Sulfonic acid; Sulfur; Sulfur metabolism; TCEP; Thiol; Thiol oxidation; Thiol peroxidases; Thiolate; Thiol-based redox signaling; Thiols; Thioredoxin; Thioredoxin reductase; Thioredoxin/thioredoxin reductase; Thiyl radical; Transnitrosation; Transsulfuration; Trypanosoma; Trypanothione; Tryparedoxin; Tyrosine; UGA
