Therapeutic Targets for Diabetic Retinopathy

1. Introduction of diabetic retinopathy and principles of treatment

Weiye Li and Jingfa Zhang

2. Diabetes-induced metabolic disorders of diabetic retinopathy

Weiye Li and Jingfa Zhang

3. Diabetic retinopathy, a neurovascular unit disease

Weiye Li and Jingfa Zhang

4. The pathogenic role of apoptosis in the development of diabetic retinopathy

Weiye Li and Jingfa Zhang

5. Diabetic retinopathy, a disease with low-grade inflammation

Weiye Li and Jingfa Zhang

6. Neurodegeneration and microangiopathy in diabetic retina and choroid

Weiye Li and Jingfa Zhang

7. Proliferative diabetic retinopathy, a disease of pathologic angiogenesis and vasculogenesis

Weiye Li and Jingfa Zhang

8. Pathogenesis of diabetic macular edema

Weiye Li and Jingfa Zhang

9. Treatments for diabetic retinopathy and diabetic macular edema in pipeline

Weiye Li and Jingfa Zhang

10. Future perspectives for diabetic retinopathy management

Weiye Li and Jingfa Zhang

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• Oftalmologia

Adaptive immunity; Advanced glycation end products; Angiogenesis; Angiopoietin 2; Angiopoietin-2; Anti-apoptosis; Anti-inflammation; Anti-VEGF; Anti-VEGF therapy; Apoptosis; Artificial intelligence; Astrocytes; Blood-retinal barrier; Blood-retinal barrier breakdown; BRB breakdown; Cell death; Cell therapy; Chemokines; Choriocapillaris; Corticosteroid therapy; Diabetic choroidopathy; Diabetic macular edema; Diabetic retinal microangiopathy; Diabetic retinal neurodegeneration; Diabetic retinal neuronopathy; Diabetic retinopathy; Diabetic vitrectomy; Drainage dysfunction; Endothelial cell; Epidemiology; Gene therapy; Genetics; Glycemic control; Hexosamine biosynthetic pathway; HIF-1?; Hypertension; Inflammation; Inflammtory cytokines; Innate; Integrin; Intracellular edema; Intussusceptive angiogenesis; Laser photocoagulation; Leukocyte adhesion; Leukostasis; Low-grade inflammation; Mueller glia; Metabolic memory; Microglia; Microglia activation; Microinflammation; Neuronal dysfunction; Neuroprotection; Neurovascular coupling; Neurovascular unit; Oxidative stress